This week we ask: Can computers help us revolutionise heart failure treatment? Join us as we explore how computational modelling is transforming cardiac pacing therapy. Discover how virtual trials are accelerating research, optimising treatment strategies, and improving patient outcomes—all before a single device is implanted. Learn how this cutting-edge approach is helping clinicians identify the right treatment for the right patient, potentially changing the future of cardiac care. A fascinating intersection of computer science and cardiology you won't want to miss. Strocchi M, Wijesuriya N, Mehta V, de Vere F, Rinaldi CA, Niederer SA. Computational Modelling Enabling In Silico Trials for Cardiac Physiologic Pacing. J Cardiovasc Transl Res. 2024 Jun;17(3):685-694. doi: 10.1007/s12265-023-10453-y.